Coordinate induction of IFN-alpha and -gamma by SARS-CoV also in the absence of virus replication.
Identifieur interne : 004884 ( Main/Exploration ); précédent : 004883; suivant : 004885Coordinate induction of IFN-alpha and -gamma by SARS-CoV also in the absence of virus replication.
Auteurs : Concetta Castilletti [Italie] ; Licia Bordi ; Eleonora Lalle ; Gabriella Rozera ; Fabrizio Poccia ; Chiara Agrati ; Isabella Abbate ; Maria R. CapobianchiSource :
- Virology [ 0042-6822 ] ; 2005.
Descripteurs français
- KwdFr :
- ARN messager (biosynthèse), ARN messager (génétique), Agranulocytes (immunologie), Agranulocytes (virologie), Animaux, Cellules Vero, Humains, Interféron alpha (biosynthèse), Interféron alpha (génétique), Interféron gamma (biosynthèse), Interféron gamma (génétique), Régulation de l'expression des gènes, Réplication virale, Techniques in vitro, Virus du SRAS (immunologie), Virus du SRAS (pathogénicité), Virus du SRAS (physiologie).
- MESH :
- biosynthèse : ARN messager, Interféron alpha, Interféron gamma.
- génétique : ARN messager, Interféron alpha, Interféron gamma.
- immunologie : Agranulocytes, Virus du SRAS.
- pathogénicité : Virus du SRAS.
- physiologie : Virus du SRAS.
- virologie : Agranulocytes.
- Animaux, Cellules Vero, Humains, Régulation de l'expression des gènes, Réplication virale, Techniques in vitro.
English descriptors
- KwdEn :
- Animals, Chlorocebus aethiops, Gene Expression Regulation, Humans, In Vitro Techniques, Interferon-alpha (biosynthesis), Interferon-alpha (genetics), Interferon-gamma (biosynthesis), Interferon-gamma (genetics), Leukocytes, Mononuclear (immunology), Leukocytes, Mononuclear (virology), RNA, Messenger (biosynthesis), RNA, Messenger (genetics), SARS Virus (immunology), SARS Virus (pathogenicity), SARS Virus (physiology), Vero Cells, Virus Replication.
- MESH :
- chemical , biosynthesis : Interferon-alpha, Interferon-gamma, RNA, Messenger.
- chemical , genetics : Interferon-alpha, Interferon-gamma, RNA, Messenger.
- immunology : Leukocytes, Mononuclear, SARS Virus.
- pathogenicity : SARS Virus.
- physiology : SARS Virus.
- virology : Leukocytes, Mononuclear.
- Animals, Chlorocebus aethiops, Gene Expression Regulation, Humans, In Vitro Techniques, Vero Cells, Virus Replication.
Abstract
Severe acute respiratory syndrome (SARS) is an emerging infection caused by a novel coronavirus known as SARS-CoV, characterized by an over-exuberant immune response with lung lymphomononuclear cells infiltration and proliferation that may account for tissue damage more than the direct effect of viral replication. This study is aimed at investigating the capability of SARS-CoV to activate IFN-alpha and -gamma expression in lymphomonocytes (PBMC) from healthy donors, evaluating whether viral replication is necessary for this activation.
DOI: 10.1016/j.virol.2005.07.015
PubMed: 16095648
Affiliations:
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Le document en format XML
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Capobianchi</name></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Gene Expression Regulation</term><term>Humans</term><term>In Vitro Techniques</term><term>Interferon-alpha (biosynthesis)</term><term>Interferon-alpha (genetics)</term><term>Interferon-gamma (biosynthesis)</term><term>Interferon-gamma (genetics)</term><term>Leukocytes, Mononuclear (immunology)</term><term>Leukocytes, Mononuclear (virology)</term><term>RNA, Messenger (biosynthesis)</term><term>RNA, Messenger (genetics)</term><term>SARS Virus (immunology)</term><term>SARS Virus (pathogenicity)</term><term>SARS Virus (physiology)</term><term>Vero Cells</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (biosynthèse)</term><term>ARN messager (génétique)</term><term>Agranulocytes (immunologie)</term><term>Agranulocytes (virologie)</term><term>Animaux</term><term>Cellules Vero</term><term>Humains</term><term>Interféron alpha (biosynthèse)</term><term>Interféron alpha (génétique)</term><term>Interféron gamma (biosynthèse)</term><term>Interféron gamma (génétique)</term><term>Régulation de l'expression des gènes</term><term>Réplication virale</term><term>Techniques in vitro</term><term>Virus du SRAS (immunologie)</term><term>Virus du SRAS (pathogénicité)</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interferon-alpha</term><term>Interferon-gamma</term><term>RNA, Messenger</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Interferon-alpha</term><term>Interferon-gamma</term><term>RNA, Messenger</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>ARN messager</term><term>Interféron alpha</term><term>Interféron gamma</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term><term>Interféron alpha</term><term>Interféron gamma</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Agranulocytes</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Leukocytes, Mononuclear</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Agranulocytes</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Leukocytes, Mononuclear</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Gene Expression Regulation</term><term>Humans</term><term>In Vitro Techniques</term><term>Vero Cells</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules Vero</term><term>Humains</term><term>Régulation de l'expression des gènes</term><term>Réplication virale</term><term>Techniques in vitro</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is an emerging infection caused by a novel coronavirus known as SARS-CoV, characterized by an over-exuberant immune response with lung lymphomononuclear cells infiltration and proliferation that may account for tissue damage more than the direct effect of viral replication. This study is aimed at investigating the capability of SARS-CoV to activate IFN-alpha and -gamma expression in lymphomonocytes (PBMC) from healthy donors, evaluating whether viral replication is necessary for this activation.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><noCountry><name sortKey="Abbate, Isabella" sort="Abbate, Isabella" uniqKey="Abbate I" first="Isabella" last="Abbate">Isabella Abbate</name><name sortKey="Agrati, Chiara" sort="Agrati, Chiara" uniqKey="Agrati C" first="Chiara" last="Agrati">Chiara Agrati</name><name sortKey="Bordi, Licia" sort="Bordi, Licia" uniqKey="Bordi L" first="Licia" last="Bordi">Licia Bordi</name><name sortKey="Capobianchi, Maria R" sort="Capobianchi, Maria R" uniqKey="Capobianchi M" first="Maria R" last="Capobianchi">Maria R. Capobianchi</name><name sortKey="Lalle, Eleonora" sort="Lalle, Eleonora" uniqKey="Lalle E" first="Eleonora" last="Lalle">Eleonora Lalle</name><name sortKey="Poccia, Fabrizio" sort="Poccia, Fabrizio" uniqKey="Poccia F" first="Fabrizio" last="Poccia">Fabrizio Poccia</name><name sortKey="Rozera, Gabriella" sort="Rozera, Gabriella" uniqKey="Rozera G" first="Gabriella" last="Rozera">Gabriella Rozera</name></noCountry><country name="Italie"><region name="Latium"><name sortKey="Castilletti, Concetta" sort="Castilletti, Concetta" uniqKey="Castilletti C" first="Concetta" last="Castilletti">Concetta Castilletti</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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